Communications of the ACM
Tiny Bio-Robot Is a Germ Suited-Up with Graphene Quantum Dots
Credit: redOrbit
As nanotechnology makes possible a world of machines too tiny to see, researchers are finding ways to combine living organisms with nonliving machinery to solve a variety of problems.
Like other first-generation bio-robots, the new nanobot engineered at the University of Illinois at Chicago is a far cry from Robocop. It's a robotic germ.
UIC researchers created an electromechanical device — a humidity sensor — on a bacterial spore. They call it NERD, for Nano-Electro-Robotic Device. Their work is described in "Graphene Quantum Dots Interfaced with Single Bacterial Spore for Bio-Electromechanical Devices: A Graphene Cytobot," published in Scientific Reports.
"We've taken a spore from a bacteria, and put graphene quantum dots on its surface — and then attached two electrodes on either side of the spore," says Vikas Berry, UIC associate professor of chemical engineering and principal investigator on the study.
"Then we change the humidity around the spore," Berry says.
When the humidity drops, the spore shrinks as water is pushed out. As it shrinks, the quantum dots come closer together, increasing their conductivity, as measured by the electrodes.
"We get a very clean response — a very sharp change the moment we change humidity," Berry says. The response was 10 times faster than a sensor made with the most advanced man-made water-absorbing polymers, he says.
There was also better sensitivity in extreme low-pressure, low-humidity situations.
"We can go all the way down to a vacuum and see a response," says Berry, which is important in applications where humidity must be kept low, for example, to prevent corrosion or food spoilage. "It's also important in space applications, where any change in humidity could signal a leak," he says.
Currently available sensors increase in sensitivity as humidity rises, Berry says. NERD's sensitivity is actually higher at low humidity.
"This is a fascinating device," Berry says. "Here we have a biological entity. We've made the sensor on the surface of these spores, with the spore a very active complement to this device. The biological complement is actually working towards responding to stimuli and providing information."
T. S. Sreeprasad and Phong Nguyen of UIC were lead co-authors on the study. Sreeprasad, a postdoctoral fellow, is now at Rice University in Houston. Ahmed Alshogeathri, Luke Hibbeler, Fabian Martinez, and Nolan McNeil, undergraduate students from Kansas State University, and Vikas Berry were also co-authors on the paper.
The study was supported by the Terry C. Johnson Center for Basic Cancer Research and partial support from the U.S. National Science Foundation (CMMI-1054877, CMMI-0939523 and CMMI-1030963) and the Office of Naval Research (N000141110767).
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