Communications of the ACM
Universal Algorithm Set to Boost Microscopes
Researchers at the Swiss Federal Institute of Technology, Lausanne have developed an algorithm that can ascertain whether a super-resolution microscope is operating at maximum resolution within seconds, from just one image.
Credit: EPFL (Switzerland)
A new algorithm developed by researchers at the Swiss Federal Institute of Technology, Lausanne (EPFL) can ascertain within seconds whether a super-resolution microscope is operating at maximum resolution, from just one image.
The technique could find use as a tool in research labs using automated microscopes.
The team based the algorithm on Fourier's transform, tweaked to derive the most data possible from a single image. The algorithm produces a single number, which scientists can compare with the microscope's maximum possible resolution, to see whether the device can function better, or attempt to upgrade the resolution by modifying experimental conditions.
Said EPFL's Adrien Descloux, "Our algorithm is universal. And because only one image is needed, it is particularly suited for fast optimization of imaging conditions, which is challenging when observing dynamic processes."
From EPFL (Switzerland)
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Abstracts Copyright © 2019 SmithBucklin, Washington, DC, USA
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