Communications of the ACM
Computer Simulation for Understanding Brain Cancer Growth
A multinational team of researchers have developed a three-dimensional simulation combining the macroscopic scale of tissue with the microscopic scale of individual cells.
Credit: Newscastle University
Researchers at Newcastle University and University College London in the U.K., the University of Cyprus, and CERN (the European Organization for Nuclear Research, based in Switzerland) have developed a three-dimensional (3D) simulation that combines the macroscopic scale of tissue with the microscopic scale of individual cells to realistically model the mechano-biology of cancer.
The freely available BioDynaMo platform includes the role of cell migration and adhesion, the influence of the extracellular matrix, the effects of oxygen and nutrient availability, and the signaling triggered by chemical cues and growth factors.
Newcastle's Jean de Montigny said, “The advantage for scientists and medics is that BioDynaMo can be used on standard laptops or desktop computers and provides a software platform which can be used to easily create, run, and visualize 3D agent-based biological simulations."
From Newcastle University
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