Communications of the ACM
Scientists Model Neural Activity From Living Human Cells on Brain-on-a-Chip Devices
Scientists at Lawrence Livermore National Laboratory have created three-dimensional brain-on-a-chip devices that mimic the neural activity of brain cells cultured outside the human body.
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Lawrence Livermore National Laboratory (LLNL) scientists have generated three-dimensional brain-on-a-chip devices that mimic the neural activity of brain cells cultured outside the human body.
The team designed, fabricated, and honed the devices with built-in multi-electrode arrays that form a culture well on which brain cells are grown.
The electrode traces extend to connectors that plug into an electrical-signal recorder, which in turn links to a computer. A temporal stochastic block model can be used to visualize and monitor neuronal networks' progress on the chips. LLNL's Nick Fischer said the goal is to create an experimental platform that delivers human-relevant data to better understand how different drugs and therapeutics impact the human brain, and develop countermeasures for those with toxic effects.
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