Communications of the ACM
Computer System Can Help Inform Future Therapies for Patients with Inherited Heart Disease
Researchers have found an integrated, genomic computer system for precision cardiology can help inform medical and surgical decisions in support of future therapies for patients with inherited heart disease.
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A computer system trained on clinical data can provide support for medical and surgical decisions on future treatment for patients with inherited heart disease.
Scientists at the Wellcome Sanger Institute and University of Cambridge in the U.K., the Massachusetts Institute of Technology (MIT) in the U.S., and Sweden's Lund University engineered the model from genomic data combined with biological and chemical data, then validated it with global data from more than 980 patients with inherited heart muscle disease.
The model can forecast how genetic variants may influence changes in troponins, or proteins involved in inherited cardiomyopathies.
MIT's Rameen Shakur said, "This study is the next step in integrating precision cardiology into clinical care, and working more closely with clinical genetics colleagues and patients with their families, bridging the gap between research and day-to-day treatment decisions."
From News-Medical Life Sciences
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