Communications of the ACM
DNA-Based Chip Can Be Programmed to Solve Complex Math Problems
The researchers used three-dimensional (3D) printing to fabricate the microfluidic chip.
Credit: Gerd Altmann/Pixabay
Scientists at South Korea's Incheon National University (INU) have automated mathematical DNA calculations via a personal computer (PC)-controlled chip.
The three-dimensionally-printed microfluidic processing unit can execute Boolean logic, with a single-stranded DNA template serving as a logic gate while different single-stranded DNA act as inputs.
If part of an input DNA possesses a complementary Watson-Crick sequence to the template DNA, it pairs into double-stranded DNA whose size signals the output as true or false.
INU's Youngjun Song said, "Our hope is that DNA-based CPUs [central-processing units] will replace electronic CPUs in the future because they consume less power, which will help with global warming. DNA-based CPUs also provide a platform for complex calculations like deep learning solutions and mathematical modeling."
From Incheon National University (South Korea)
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