Communications of the ACM
Cyborg Technology Analyzes Functional Maturation of Stem-Cell Derived Heart Tissue
Said Harvard's Jia Liu, “Nature showed us the solution to monitoring tissue in 3D. We were inspired by the way neural tubes fold during development, stretching as cells migrate and take shape into tissue volume.”
Credit: Liu Lab/Harvard SEAS
A "cyborg" technique developed by Harvard University researchers can monitor the functional maturation of heart tissue using nanoelectronics.
Said Harvard's Jia Liu, "These mesh-like nanoelectronics, designed to stretch and move with growing tissue, can continuously capture long-term activity within individual stem-cell derived cardiomyocytes of interest."
The researchers grew cells onto a sheet composed of cellular matrix called Matrigel and the nanoelectronic sensor.
They observed the cardiomyocytes undergoing "extraordinary electrical maturation" when in close proximity to endothelial cells.
In conjunction with machine learning-based analysis to interpret this activity, Liu said the method offers a platform for monitoring and operating stem cell-based tissue implants.
From Harvard University John A. Paulson School of Engineering and Applied Sciences
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