Communications of the ACM
Pills from the 3D Printer
The researchers used mathematical modelling and experiments to determine which tablet shape releases the desired quantity of an active ingredient during dissolution in the digestive tract.
Credit: MPI-INF
Computer scientists at Germany's Max Planck Institute for Informatics and the University of California at Davis have three-dimensionally (3D)-printed liquid-soluble tablets, using mathematical models to determine configurations that release the desired amount of active ingredients.
The researchers use topology optimization to characterize the temporal profile for the tablet to release its load, then calculate the matching shape with a model that captures the liquid dissolution of differently-shaped geometric figures.
They employ a water-soluble material to 3D-print these shapes.
The approach also can factor in the limitation of shape options by the manufacturing process.
From Max Planck Gesellschaft (Germany)
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