Communications of the ACM
3D Printing Method Shows Promise for Repairing Brain Injuries
Tissue regenerative therapies, especially those in which patients are given implants derived from their own stem cells, could be a promising route to treat brain injuries in the future.
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Scientists at the U.K.'s University of Oxford three-dimensionally (3D)-printed human neural cells to emulate the cerebral cortex's architecture.
The researchers differentiated human-induced pluripotent stem cells into neural progenitor cells to form two distinct layers, then suspended them in solution to produce "bioinks" for printing into two-layered brain tissue.
The 3D-printed tissues exhibited strong integration when implanted into mouse brain slices; their signaling activity corresponded with that of the host cells.
Said Oxford's Linna Zhou, "Our droplet printing technique provides a means to engineer living 3D tissues with desired architectures, which brings us closer to the creation of personalized implantation treatments for brain injury."
From University of Oxford (U.K.)
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