Communications of the ACM
Computer-Engineered DNA to Study Cell Identities
The algorithm will be used to screen for anti-cancer or viral infections drugs, or to improve gene and cell-based immunotherapies.
Credit: Mattias Schmidt (AG Gargiulo), Max Delbrück Center
An algorithm developed by researchers at Germany's Max Delbrück Center for Molecular Medicine (MDC) can be used to design synthetic DNA segments that provide real-time information about the identity and state of cells.
The LSD (logical design of synthetic cis-regulatory DNA) algorithm could be leveraged to improve gene- and cell-based immunotherapies and screen for anti-cancer or anti-viral drugs.
After inputting known genes and transcription factors associated with the specific cell states being studied, the LSD algorithm identifies the DNA segments that control the activity in the cell of interest, constructing the cell's "synthetic locus control region" without knowing the exact genetic or molecular reason for the cell's behavior.
From Max Delbrück Center for Molecular Medicine (Germany)
View Full Article
Abstracts Copyright © 2024 SmithBucklin, Washington, D.C., USA
No entries found